An Interplay Between MRTF-A and the Histone Acetyltransferase TIP60 Mediates Hypoxia-Reoxygenation Induced iNOS Transcription in Macrophages

An Interplay Between MRTF-A and the Histone Acetyltransferase TIP60 Mediates Hypoxia-Reoxygenation Induced iNOS Transcription in Macrophages

Cardiac ischemia-reperfusion injury (IRI) represents a major pathophysiological event associated with permanent loss of heart function. Several inter-dependent processes contribute to cardiac IRI that include accumulation of reactive oxygen species (ROS), aberrant inflammatory response, and depletio...

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Bibliographic Details
Main Authors: Yuyu Yang, Guang Yang, Liming Yu, Ling Lin, Li Liu, Mingming Fang, Yong Xu
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-06-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
transcriptional regulation
epigenetics
macrophages
cardiac ischemia-reperfusion injury
iNOS
Online Access:https://www.frontiersin.org/article/10.3389/fcell.2020.00484/full

Internet

https://www.frontiersin.org/article/10.3389/fcell.2020.00484/full

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