MiR-7e-5p downregulation promotes transformation of low-grade follicular lymphoma to aggressive lymphoma by modulating an immunosuppressive stroma through the upregulation of FasL in M1 macrophages

MiR-7e-5p downregulation promotes transformation of low-grade follicular lymphoma to aggressive lymphoma by modulating an immunosuppressive stroma through the upregulation of FasL in M1 macrophages

Abstract Background In follicular lymphoma (FL), histologic transformation to high-grade FL and diffuse large B-cell lymphoma (DLBCL) is a critical adverse step in disease progression. Activation of the oncogene c-MYC and tumor microenvironment remodeling account for FL progression. A panel of micro...

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Bibliographic Details
Main Authors: Xiaoli Lou, Jianhong Fu, Xin Zhao, Xuemei Zhuansun, Chao Rong, Maomin Sun, Hui Niu, Lei Wu, Yongsheng Zhang, Lu An, Lingchuan Guo, Shan Wan, Shouli Wang
Format: Article
Language:English
Published: BMC 2020-11-01
Series:Journal of Experimental & Clinical Cancer Research
Subjects:
Follicular lymphoma
miR-7e
C-MYC
FasL
Macrophage
PARP
Online Access:http://link.springer.com/article/10.1186/s13046-020-01747-z

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http://link.springer.com/article/10.1186/s13046-020-01747-z

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