Statins Mitigate Stress-Related Vascular Aging and Atherosclerosis in apoE-Deficient Mice Fed High Fat-Diet: The Role of Glucagon-Like Peptide-1/Adiponectin Axis

Statins Mitigate Stress-Related Vascular Aging and Atherosclerosis in apoE-Deficient Mice Fed High Fat-Diet: The Role of Glucagon-Like Peptide-1/Adiponectin Axis

ObjectivesExposure to chronic psychosocial stress is a risk factor for atherosclerotic cardiovascular diseases. Given that the 3-hydroxy-3-methylglutaryl-coenzyme reductase inhibitor statins prevent atherogenesis, we evaluated whether pitavastatin prevents chronic stress- and high fat diet-induced v...

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Bibliographic Details
Main Authors: Yanna Lei, Qingsong Cui, Guang Yang, Limei Piao, Aiko Inoue, Hongxian Wu, Xiang Li, Masafumi Kuzuya, Xian Wu Cheng
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-07-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
chronic stress
statins
atherosclerosis
inflammation
adiponectin
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2021.687868/full

Internet

https://www.frontiersin.org/articles/10.3389/fcell.2021.687868/full

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