The NLRP3 Inflammasome Suppresses Protective Immunity to Gastrointestinal Helminth Infection

The NLRP3 Inflammasome Suppresses Protective Immunity to Gastrointestinal Helminth Infection

Summary: Inflammasomes promote immunity to microbial pathogens by regulating the function of IL-1-family cytokines such as IL-18 and IL-1β. However, the roles for inflammasomes during parasitic helminth infections remain unclear. We demonstrate that mice and humans infected with gastrointestinal nem...

Full description

Bibliographic Details
Main Authors: Rafid Alhallaf, Zainab Agha, Catherine M. Miller, Avril A.B. Robertson, Javier Sotillo, John Croese, Matthew A. Cooper, Seth L. Masters, Andreas Kupz, Nicholas C. Smith, Alex Loukas, Paul R. Giacomin
Format: Article
Language:English
Published: Elsevier 2018-04-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S221112471830473X

Internet

http://www.sciencedirect.com/science/article/pii/S221112471830473X

Similar Items