Gancao (Glycyrrhizae Radix) provides the main contribution to Shaoyao-Gancao decoction on enhancements of CYP3A4 and MDR1 expression via pregnane X receptor pathway in vitro

Gancao (Glycyrrhizae Radix) provides the main contribution to Shaoyao-Gancao decoction on enhancements of CYP3A4 and MDR1 expression via pregnane X receptor pathway in vitro

Abstract Background Chinese herbal formula Shaoyao Gancao decoction (SGD) is often used as an adjuvant with chemotherapeutic agents to treat cancer. Due to the herb-drug interactions, the alternations of drug metabolic enzyme and drug transporters induced by SGD deserve to be explored. We aimed to i...

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Bibliographic Details
Main Authors: Dandan Feng, Tao Tang, Rong Fan, Jiekun Luo, Hanjin Cui, Yang Wang, Pingping Gan
Format: Article
Language:English
Published: BMC 2018-12-01
Series:BMC Complementary and Alternative Medicine
Subjects:
Shaoyao Gancao decoction
Pregnane X receptor
Cytochrome P450 3A4
Multidrug resistance protein 1
Traditional Chinese medicine
Online Access:http://link.springer.com/article/10.1186/s12906-018-2402-7

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http://link.springer.com/article/10.1186/s12906-018-2402-7

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