Differential Aggregation and Phosphorylation of Alpha Synuclein in Membrane Compartments Associated With Parkinson Disease

Differential Aggregation and Phosphorylation of Alpha Synuclein in Membrane Compartments Associated With Parkinson Disease

The aggregation of α-synuclein (α-syn) is a major factor behind the onset of Parkinson’s disease (PD). Sublocalization of this protein may be relevant for the formation of multimeric α-syn oligomeric configurations, insoluble aggregates that form Lewy bodies in PD brains. Processing of this protein...

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Bibliographic Details
Main Authors: Ana Canerina-Amaro, Daniel Pereda, Mario Diaz, Deiene Rodriguez-Barreto, Verónica Casañas-Sánchez, Marija Heffer, Paula Garcia-Esparcia, Isidro Ferrer, Ricardo Puertas-Avendaño, Raquel Marin
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-04-01
Series:Frontiers in Neuroscience
Subjects:
alpha synuclein
Parkinson disease
lipid rafts
prion protein
amyloid precursor protein
metabotropic glutamate receptor 5
Online Access:https://www.frontiersin.org/article/10.3389/fnins.2019.00382/full

Internet

https://www.frontiersin.org/article/10.3389/fnins.2019.00382/full

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