Blockade of MCAM/CD146 impedes CNS infiltration of T cells over the choroid plexus

Blockade of MCAM/CD146 impedes CNS infiltration of T cells over the choroid plexus

Abstract Background Very late antigen 4 (VLA-4; integrin α4β1) is critical for transmigration of T helper (TH) 1 cells into the central nervous system (CNS) under inflammatory conditions such as multiple sclerosis (MS). We have previously shown that VLA-4 and melanoma cell adhesion molecule (MCAM) a...

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Bibliographic Details
Main Authors: Johanna Breuer, Eva Korpos, Melanie-Jane Hannocks, Tilman Schneider-Hohendorf, Jian Song, Lisa Zondler, Sebastian Herich, Ken Flanagan, Thomas Korn, Alexander Zarbock, Tanja Kuhlmann, Lydia Sorokin, Heinz Wiendl, Nicholas Schwab
Format: Article
Language:English
Published: BMC 2018-08-01
Series:Journal of Neuroinflammation
Subjects:
MCAM
VLA-4
CNS-migration
Choroid plexus
Laminin 411
EAE
Online Access:http://link.springer.com/article/10.1186/s12974-018-1276-4

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http://link.springer.com/article/10.1186/s12974-018-1276-4

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