Development of RP-HPLC, Stability Indicating Method for Degradation Products of Linagliptin in Presence of Metformin HCl by Applying 2 Level Factorial Design; and Identification of Impurity-VII, VIII and IX and Synthesis of Impurity-VII

Development of RP-HPLC, Stability Indicating Method for Degradation Products of Linagliptin in Presence of Metformin HCl by Applying 2 Level Factorial Design; and Identification of Impurity-VII, VIII and IX and Synthesis of Impurity-VII

The novel reverse phase-high performance liquid chromatography (RP-HPLC), stability indicating method was developed for determination of linagliptin (LGP) and its related substances in linagliptin and metformin HCl (MET HCl) tablets by implementing design of experiment to understand the critical met...

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Bibliographic Details
Main Authors: Sushant B. Jadhav, P. Sunil Reddy, Kalyanaraman L. Narayanan, Popatrao N. Bhosale
Format: Article
Language:English
Published: Österreichische Apotheker-Verlagsgesellschaft m. b. H. 2017-06-01
Series:Scientia Pharmaceutica
Subjects:
HPLC
design of experiments
full factorial design
development and validation
linagliptin and metformin HCl
Online Access:http://www.mdpi.com/2218-0532/85/3/25

Internet

http://www.mdpi.com/2218-0532/85/3/25

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