Asymmetric Construction of All-Carbon Quaternary Stereocenters by Chiral-Auxiliary-Mediated Claisen Rearrangement and Total Synthesis of (+)-Bakuchiol

Asymmetric Construction of All-Carbon Quaternary Stereocenters by Chiral-Auxiliary-Mediated Claisen Rearrangement and Total Synthesis of (+)-Bakuchiol

An asymmetric Claisen rearrangement using Oppolzer’s camphorsultam was developed. Under thermal conditions, a geraniol-derived substrate underwent the rearrangement with good stereoselectivity. The absolute configuration of the newly formed all-carbon quaternary stereocenter was confir...

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Bibliographic Details
Main Authors: Kin-ichi Tadano, Yusuke Kusakawa, Marianne Ayaka Touati, Shu Sakamoto, Ken-ichi Takao
Format: Article
Language:English
Published: MDPI AG 2012-11-01
Series:Molecules
Subjects:
Claisen rearrangement
chiral auxiliary
camphorsultam
quaternary stereocenter
total synthesis
Online Access:http://www.mdpi.com/1420-3049/17/11/13330

Internet

http://www.mdpi.com/1420-3049/17/11/13330

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