Synthesis and Biological Evaluation of Lipophilic Nucleoside Analogues as Inhibitors of Aminoacyl-tRNA Synthetases

Synthesis and Biological Evaluation of Lipophilic Nucleoside Analogues as Inhibitors of Aminoacyl-tRNA Synthetases

Emerging antibiotic resistance in pathogenic bacteria and reduction of compounds in the existing antibiotics discovery pipeline is the most critical concern for healthcare professionals. A potential solution aims to explore new or existing targets/compounds. Inhibition of bacterial aminoacyl-tRNA sy...

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Bibliographic Details
Main Authors: Manesh Nautiyal, Bharat Gadakh, Steff De Graef, Luping Pang, Masroor Khan, Yi Xun, Jef Rozenski, Arthur Van Aerschot
Format: Article
Language:English
Published: MDPI AG 2019-10-01
Series:Antibiotics
Subjects:
aminoacyl-trna synthetase
aminoacylated sulfamoyladenosines
bisubstrate competitive inhibitor
prodrugs
lipophilic adenosines
enzyme inhibition
antibacterial activity
Online Access:https://www.mdpi.com/2079-6382/8/4/180

Internet

https://www.mdpi.com/2079-6382/8/4/180

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