Cell-Based Radiotracer Binding and Uptake Inhibition Assays: A Comparison of In Vitro Methods to Assess the Potency of Drugs That Target Monoamine Transporters

Cell-Based Radiotracer Binding and Uptake Inhibition Assays: A Comparison of In Vitro Methods to Assess the Potency of Drugs That Target Monoamine Transporters

High-affinity monoamine transporters are targets for prescribed medications and stimulant drugs of abuse. Therefore, assessing monoamine transporter activity for candidate medications and newly-emerging drugs of abuse provides essential information for industry, academia, and public health. Radiotra...

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Bibliographic Details
Main Authors: Marija Ilic, Marion Holy, Kathrin Jaentsch, Matthias E. Liechti, Gert Lubec, Michael H. Baumann, Harald H. Sitte, Dino Luethi
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-05-01
Series:Frontiers in Pharmacology
Subjects:
monoamine
transporter
radiotracer
stimulant
synaptosomes
HEK 293
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2020.00673/full

Internet

https://www.frontiersin.org/article/10.3389/fphar.2020.00673/full

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