Mus musculus deficient for secretory antibodies show delayed growth with an altered urinary metabolome

Mus musculus deficient for secretory antibodies show delayed growth with an altered urinary metabolome

Abstract Background The polymeric immunoglobulin receptor (pIgR) maintains the integrity of epithelial barriers by transporting polymeric antibodies and antigens through the epithelial mucosa into the lumen. In this study, we examined the role of pIgR in maintaining gut barrier integrity, which is i...

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Bibliographic Details
Main Authors: Kim R. Simpfendorfer, Nancy Wang, Dedreia L. Tull, David P. De Souza, Amsha Nahid, Andre Mu, Dianna M. Hocking, John S. Pedersen, Odilia L. C. Wijburg, Malcolm J. McConville, Richard A. Strugnell
Format: Article
Language:English
Published: BMC 2019-04-01
Series:Molecular Medicine
Subjects:
SIgA
Inflammation
Gut
Permeability
Urinary biomarker
Tissue resident memory T cells
Online Access:http://link.springer.com/article/10.1186/s10020-019-0077-2

Internet

http://link.springer.com/article/10.1186/s10020-019-0077-2

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