The CNS in inbred transgenic models of 4-repeat Tauopathy develops consistent tau seeding capacity yet focal and diverse patterns of protein deposition

The CNS in inbred transgenic models of 4-repeat Tauopathy develops consistent tau seeding capacity yet focal and diverse patterns of protein deposition

Abstract Background MAPT mutations cause neurodegenerative diseases such as frontotemporal dementia but, strikingly, patients with the same mutation may have different clinical phenotypes. Methods Given heterogeneities observed in a transgenic (Tg) mouse line expressing low levels of human (2 N, 4R)...

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Bibliographic Details
Main Authors: Ghazaleh Eskandari-Sedighi, Nathalie Daude, Hristina Gapeshina, David W. Sanders, Razieh Kamali-Jamil, Jing Yang, Beipei Shi, Holger Wille, Bernardino Ghetti, Marc I. Diamond, Christopher Janus, David Westaway
Format: Article
Language:English
Published: BMC 2017-10-01
Series:Molecular Neurodegeneration
Subjects:
Stochastic events
Aging
P301L mutation
Focal pathology
Neuronal loss
Transgenic mouse
Online Access:http://link.springer.com/article/10.1186/s13024-017-0215-7

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http://link.springer.com/article/10.1186/s13024-017-0215-7

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