Comparative profiling of the synaptic proteome from Alzheimer’s disease patients with focus on the APOE genotype

Comparative profiling of the synaptic proteome from Alzheimer’s disease patients with focus on the APOE genotype

Abstract Degeneration of synapses in Alzheimer’s disease (AD) strongly correlates with cognitive decline, and synaptic pathology contributes to disease pathophysiology. We recently observed that the strongest genetic risk factor for sporadic AD, apolipoprotein E epsilon 4 (APOE4), is associated with...

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Bibliographic Details
Main Authors: Raphael Hesse, Maica Llavero Hurtado, Rosemary J. Jackson, Samantha L. Eaton, Abigail G. Herrmann, Marti Colom-Cadena, Makis Tzioras, Declan King, Jamie Rose, Jane Tulloch, Chris-Anne McKenzie, Colin Smith, Christopher M. Henstridge, Douglas Lamont, Thomas M. Wishart, Tara L. Spires-Jones
Format: Article
Language:English
Published: BMC 2019-12-01
Series:Acta Neuropathologica Communications
Subjects:
Alzheimer
Synapse
Apolipoporotein E
Proteomics
Online Access:https://doi.org/10.1186/s40478-019-0847-7

Internet

https://doi.org/10.1186/s40478-019-0847-7

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