Impaired synaptic clustering of postsynaptic density proteins and altered signal transmission in hippocampal neurons, and disrupted learning behavior in PDZ1 and PDZ2 ligand binding-deficient PSD-95 knockin mice

Impaired synaptic clustering of postsynaptic density proteins and altered signal transmission in hippocampal neurons, and disrupted learning behavior in PDZ1 and PDZ2 ligand binding-deficient PSD-95 knockin mice

<p>Abstract</p> <p>Background</p> <p>Postsynaptic density (PSD)-95-like membrane-associated guanylate kinases (PSD-MAGUKs) are scaffold proteins in PSDs that cluster signaling molecules near NMDA receptors. PSD-MAGUKs share a common domain structure, including three PDZ...

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Bibliographic Details
Main Authors: Nagura Hitoshi, Ishikawa Yasuyuki, Kobayashi Katsunori, Takao Keizo, Tanaka Tomo, Nishikawa Kouki, Tamura Hideki, Shiosaka Sadao, Suzuki Hidenori, Miyakawa Tsuyoshi, Fujiyoshi Yoshinori, Doi Tomoko
Format: Article
Language:English
Published: BMC 2012-12-01
Series:Molecular Brain
Subjects:
PSD-MAGUK
Synaptic clustering
PDZ domain
PSD-95
Synaptic transmission
Dentate gyrus
Behavioral test battery
Online Access:http://www.molecularbrain.com/content/5/1/43

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http://www.molecularbrain.com/content/5/1/43

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