Structural mechanism of ER retrieval of MHC class I by cowpox.

Structural mechanism of ER retrieval of MHC class I by cowpox.

One of the hallmarks of viral immune evasion is the capacity to disrupt major histocompatibility complex class I (MHCI) antigen presentation to evade T-cell detection. Cowpox virus encoded protein CPXV203 blocks MHCI surface expression by exploiting the KDEL-receptor recycling pathway, and here we s...

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Bibliographic Details
Main Authors: William H McCoy, Xiaoli Wang, Wayne M Yokoyama, Ted H Hansen, Daved H Fremont
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS Biology
Online Access:http://europepmc.org/articles/PMC3507924?pdf=render

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http://europepmc.org/articles/PMC3507924?pdf=render

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