Pharmacological treatment and BBB-targeted genetic therapy for MCT8-dependent hypomyelination in zebrafish

Pharmacological treatment and BBB-targeted genetic therapy for MCT8-dependent hypomyelination in zebrafish

Hypomyelination is a key symptom of Allan-Herndon-Dudley syndrome (AHDS), a psychomotor retardation associated with mutations in the thyroid-hormone (TH) transporter MCT8 (monocarboxylate transporter 8). AHDS is characterized by severe intellectual deficiency, neuromuscular impairment and brain hypo...

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Bibliographic Details
Main Authors: David Zada, Adi Tovin, Tali Lerer-Goldshtein, Lior Appelbaum
Format: Article
Language:English
Published: The Company of Biologists 2016-11-01
Series:Disease Models & Mechanisms
Subjects:
Psychomotor-retardation
Live imaging
Zebrafish
Myelin
Thyroid
Mct8
Blood–brain barrier
Allan-Herndon-Dudley syndrome (AHDS)
Online Access:http://dmm.biologists.org/content/9/11/1339

Internet

http://dmm.biologists.org/content/9/11/1339

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