Accelerated transsulfuration metabolically defines a discrete subclass of amyotrophic lateral sclerosis patients

Accelerated transsulfuration metabolically defines a discrete subclass of amyotrophic lateral sclerosis patients

Amyotrophic lateral sclerosis is a disease characterized by progressive paralysis and death. Most ALS-cases are sporadic (sALS) and patient heterogeneity poses challenges for effective therapies. Applying metabolite profiling on 77-sALS patient-derived-fibroblasts and 43-controls, we found ~25% of s...

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Bibliographic Details
Main Authors: Qiuying Chen, Csaba Konrad, Davinder Sandhu, Dipa Roychoudhury, Benjamin I. Schwartz, Roger R. Cheng, Kirsten Bredvik, Hibiki Kawamata, Elizabeth L. Calder, Lorenz Studer, Steven.M. Fischer, Giovanni Manfredi, Steven.S. Gross
Format: Article
Language:English
Published: Elsevier 2020-10-01
Series:Neurobiology of Disease
Subjects:
Sporadic amyotrophic lateral sclerosis
Metabolomics
Stable isotope tracing
Transsulfuration
Cysteine
Methionine
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996120303004

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http://www.sciencedirect.com/science/article/pii/S0969996120303004

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