Multiple model-informed open-loop control of uncertain intracellular signaling dynamics.

Computational approaches to tune the activation of intracellular signal transduction pathways both predictably and selectively will enable researchers to explore and interrogate cell biology with unprecedented precision. Techniques to control complex nonlinear systems typically involve the applicati...

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Bibliographic Details
Main Authors: Jeffrey P Perley, Judith Mikolajczak, Marietta L Harrison, Gregery T Buzzard, Ann E Rundell
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-04-01
Series:PLoS Computational Biology
Online Access:http://europepmc.org/articles/PMC3983080?pdf=render