CMTM6-Deficient Monocytes in ANCA-Associated Vasculitis Fail to Present the Immune Checkpoint PD-L1

CMTM6-Deficient Monocytes in ANCA-Associated Vasculitis Fail to Present the Immune Checkpoint PD-L1

ObjectivesANCA-associated vasculitides (AAV) affect small- and medium-sized blood vessels. In active disease, vessel wall infiltrates are mainly composed of monocytes and macrophages. Immune checkpoint molecules are crucial for the maintenance of self-tolerance and the prevention of autoimmune disea...

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Bibliographic Details
Main Authors: Markus Zeisbrich, Nina Chevalier, Bettina Sehnert, Marta Rizzi, Nils Venhoff, Jens Thiel, Reinhard E. Voll
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-05-01
Series:Frontiers in Immunology
Subjects:
ANCA vasculitis
PD-L1
macrophages
lysosomes
immune checkpoint
vasculitis < rheumatic diseases
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.673912/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2021.673912/full

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