Synthesis, characterization and in vitro inhibition of metal complexes of pyrazole based sulfonamide on human erythrocyte carbonic anhydrase isozymes I and II

Synthesis, characterization and in vitro inhibition of metal complexes of pyrazole based sulfonamide on human erythrocyte carbonic anhydrase isozymes I and II

Sulfonamides represent an important class of biologically active compounds. A sulfonamide possessing carbonic anhydrase (CA) inhibitory properties obtained from a pyrazole based sulfonamide, ethyl 1-(3-nitrophenyl)-5-phenyl-3-((5-sulfamoyl-1,3,4-thiadiazol-2-yl)carbamoyl)-1H-pyrazole-4-carboxylate (...

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Bibliographic Details
Main Authors: Nurgün Büyükkıdan, Bülent Büyükkıdan, Metin Bülbül, Rahmi Kasımoğulları, Samet Mert
Format: Article
Language:English
Published: Taylor & Francis Group 2017-01-01
Series:Journal of Enzyme Inhibition and Medicinal Chemistry
Subjects:
Carbonic anhydrase
hydratase and esterase activities
metal complexes
pyrazole
sulfonamide
Online Access:http://dx.doi.org/10.1080/14756366.2016.1247056

Internet

http://dx.doi.org/10.1080/14756366.2016.1247056

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