Computer-Aided Strategies for Determining the Amino Acid Composition of Medium for Chinese Hamster Ovary Cell-Based Biomanufacturing Platforms

Computer-Aided Strategies for Determining the Amino Acid Composition of Medium for Chinese Hamster Ovary Cell-Based Biomanufacturing Platforms

Chinese hamster ovary (CHO) cells are used for the production of the majority of biopharmaceutical drugs, and thus have remained the standard industry host for the past three decades. The amino acid composition of the medium plays a key role in commercial scale biologics manufacturing, as amino acid...

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Bibliographic Details
Main Authors: Bergthor Traustason, Matthew Cheeks, Duygu Dikicioglu
Format: Article
Language:English
Published: MDPI AG 2019-11-01
Series:International Journal of Molecular Sciences
Subjects:
chinese hamster ovary
medium development
amino acid
heterologous expression
biologics
biomanufacturing
metabolic models
design of experiments
Online Access:https://www.mdpi.com/1422-0067/20/21/5464

Internet

https://www.mdpi.com/1422-0067/20/21/5464

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