Cofactor-mediated conformational control in the bifunctional kinase/RNase Ire1
<p>Abstract</p> <p>Background</p> <p>Ire1 is a signal transduction protein in the endoplasmic reticulum (ER) membrane that serves to adjust the protein-folding capacity of the ER according to the needs of the cell. Ire1 signals, in a transcriptional program, the unfolde...
Main Authors: | Stroud Robert M, Finer-Moore Janet, Korostelev Andrei A, Egea Pascal F, Korennykh Alexei V, Zhang Chao, Shokat Kevan M, Walter Peter |
---|---|
Format: | Article |
Language: | English |
Published: |
BMC
2011-07-01
|
Series: | BMC Biology |
Online Access: | http://www.biomedcentral.com/1741-7007/9/48 |
Similar Items
-
Structural and functional basis for RNA cleavage by Ire1
by: Stroud Robert M, et al.
Published: (2011-07-01) -
Activation of the IRE1 RNase through remodeling of the kinase front pocket by ATP-competitive ligands
by: Elena Ferri, et al.
Published: (2020-12-01) -
Characterisation of the contribution of the kinase and RNase activities of Ire1α to activation of apoptotic JNK signalling
by: Watson, Jamie Nicholas
Published: (2017) -
Small molecule inhibition of IRE1α kinase/RNase has anti-fibrotic effects in the lung.
by: Maike Thamsen, et al.
Published: (2019-01-01) -
Dual IRE1 RNase functions dictate glioblastoma development
by: Stéphanie Lhomond, et al.
Published: (2018-03-01)