Myelination in Multiple Sclerosis Lesions Is Associated with Regulation of Bone Morphogenetic Protein 4 and Its Antagonist Noggin

Myelination in Multiple Sclerosis Lesions Is Associated with Regulation of Bone Morphogenetic Protein 4 and Its Antagonist Noggin

Remyelination is a central aspect of new multiple sclerosis (MS) therapies, in which one aims to alleviate disease symptoms by improving axonal protection. However, a central problem is mediators expressed in MS lesions that prevent effective remyelination. Bone morphogenetic protein4 (BMP4) inhibit...

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Bibliographic Details
Main Authors: Kim Harnisch, Sarah Teuber-Hanselmann, Nicole Macha, Fabian Mairinger, Lena Fritsche, Daniel Soub, Edgar Meinl, Andreas Junker
Format: Article
Language:English
Published: MDPI AG 2019-01-01
Series:International Journal of Molecular Sciences
Subjects:
multiple sclerosis
remyelination
remyelination block
bone morphogenetic protein 4
BMP4
Noggin
Online Access:http://www.mdpi.com/1422-0067/20/1/154

Internet

http://www.mdpi.com/1422-0067/20/1/154

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