The Oncometabolite 5′-Deoxy-5′-Methylthioadenosine Blocks Multiple Signaling Pathways of NK Cell Activation

The Oncometabolite 5′-Deoxy-5′-Methylthioadenosine Blocks Multiple Signaling Pathways of NK Cell Activation

Tumor cells develop various mechanisms to escape immune surveillance. In this context, oncometabolites secreted by tumor cells due to deregulated metabolic pathways, have been in the spotlight of researchers during the last years. 5′-Deoxy-5′-methylthioadenosine (MTA) phosphorylase (MTAP) deficiency...

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Bibliographic Details
Main Authors: Benedikt Jacobs, Sebastian Schlögl, Carolin Dorothea Strobl, Simon Völkl, Andrej Stoll, Dimitrios Mougiakakos, Karl-Johan Malmberg, Andreas Mackensen, Michael Aigner
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-10-01
Series:Frontiers in Immunology
Subjects:
NKG2C
CD16 signaling
5′-deoxy-5′-methylthioadenosine
NK cells
tumor escape mechanism
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2020.02128/full

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