Identification of 4-aminoquinoline core for the design of new cholinesterase inhibitors

Inhibition of acetylcholinesterase (AChE) using small molecules is still one of the most successful therapeutic strategies in the treatment of Alzheimer’s disease (AD). Previously we reported compound T5369186 with a core of quinolone as a new cholinesterase inhibitor. In the present study, in order...

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Bibliographic Details
Main Authors: Yao Chen, Yaoyao Bian, Yuan Sun, Chen Kang, Sheng Yu, Tingming Fu, Wei Li, Yuqiong Pei, Haopeng Sun
Format: Article
Language:English
Published: PeerJ Inc. 2016-07-01
Series:PeerJ
Subjects:
Online Access:https://peerj.com/articles/2140.pdf