Clonal haematopoiesis harbouring AML-associated mutations is ubiquitous in healthy adults

Clonal haematopoiesis has been thought to occur in less than 10% of individuals younger than 70 years old. Here, the authors use an error corrected next-generation sequencing method to find clonal haematopoiesis in the peripheral blood of 19 of 20 healthy 50–70 year old individuals.

Bibliographic Details
Main Authors: Andrew L. Young, Grant A. Challen, Brenda M. Birmann, Todd E. Druley
Format: Article
Language:English
Published: Nature Publishing Group 2016-08-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/ncomms12484