PI3K as Mediator of Apoptosis and Contractile Dysfunction in TGFβ<sub>1</sub>-Stimulated Cardiomyocytes

PI3K as Mediator of Apoptosis and Contractile Dysfunction in TGFβ<sub>1</sub>-Stimulated Cardiomyocytes

Background: TGFβ<sub>1</sub> is a growth factor that plays a major role in the remodeling process of the heart by inducing cardiomyocyte dysfunction and apoptosis, as well as fibrosis thereby restricting heart function. TGFβ<sub>1</sub> mediates its effect via the TGFβ recept...

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Bibliographic Details
Main Authors: Paulin Brosinsky, Julia Bornbaum, Björn Warga, Lisa Schulz, Klaus-Dieter Schlüter, Alessandra Ghigo, Emilio Hirsch, Rainer Schulz, Gerhild Euler, Jacqueline Heger
Format: Article
Language:English
Published: MDPI AG 2021-07-01
Series:Biology
Subjects:
TGFβ<sub>1</sub>
PI3K
cardiomyocytes
apoptosis
contractile function
SMAD
Online Access:https://www.mdpi.com/2079-7737/10/7/670

Internet

https://www.mdpi.com/2079-7737/10/7/670

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