Phosphorylation of Def Regulates Nucleolar p53 Turnover and Cell Cycle Progression through Def Recruitment of Calpain3.

Phosphorylation of Def Regulates Nucleolar p53 Turnover and Cell Cycle Progression through Def Recruitment of Calpain3.

Digestive organ expansion factor (Def) is a nucleolar protein that plays dual functions: it serves as a component of the ribosomal small subunit processome for the biogenesis of ribosomes and also mediates p53 degradation through the cysteine proteinase calpain-3 (CAPN3). However, nothing is known a...

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Bibliographic Details
Main Authors: Yihong Guan, Delai Huang, Feng Chen, Ce Gao, Ting Tao, Hui Shi, Shuyi Zhao, Zuyuan Liao, Li Jan Lo, Yingchun Wang, Jun Chen, Jinrong Peng
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2016-09-01
Series:PLoS Biology
Online Access:http://europepmc.org/articles/PMC5033581?pdf=render

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http://europepmc.org/articles/PMC5033581?pdf=render

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