Long and short-term CDK5 knockdown prevents spatial memory dysfunction and tau pathology of triple transgenic Alzheimer´s mice

Long and short-term CDK5 knockdown prevents spatial memory dysfunction and tau pathology of triple transgenic Alzheimer´s mice

CDK5 is a member of the cyclin-dependent kinase family with diverse functions in both the developing and mature nervous system. The inappropriate activation of CDK5 due to the proteolytic release of the activator fragment p25 from the membrane contributes to the formation of neurofibrillary tangles...

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Bibliographic Details
Main Authors: John Fredy Castro-Alvarez, Sergio Alejandro Uribe-Arias, Kenneth S Kosik, Gloria Patricia eCardona-Gomez
Format: Article
Language:English
Published: Frontiers Media S.A. 2014-09-01
Series:Frontiers in Aging Neuroscience
Subjects:
Alzheimer’s disease
cognitive dysfunction
tau pathology
CDK5RNAi
long-term gene therapy.
Online Access:http://journal.frontiersin.org/Journal/10.3389/fnagi.2014.00243/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fnagi.2014.00243/full

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