CD8+-T Cells With Specificity for a Model Antigen in Cardiomyocytes Can Become Activated After Transverse Aortic Constriction but Do Not Accelerate Progression to Heart Failure

CD8+-T Cells With Specificity for a Model Antigen in Cardiomyocytes Can Become Activated After Transverse Aortic Constriction but Do Not Accelerate Progression to Heart Failure

Heart failure due to pressure overload is frequently associated with inflammation. In addition to inflammatory responses of the innate immune system, autoimmune reactions of the adaptive immune system appear to be triggered in subgroups of patients with heart failure as demonstrated by the presence...

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Bibliographic Details
Main Authors: Carina Gröschel, André Sasse, Sebastian Monecke, Charlotte Röhrborn, Leslie Elsner, Michael Didié, Verena Reupke, Gertrude Bunt, Andrew H. Lichtman, Karl Toischer, Wolfram-Hubertus Zimmermann, Gerd Hasenfuß, Ralf Dressel
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-11-01
Series:Frontiers in Immunology
Subjects:
autoimmunity
autoantigen
pressure overload
cytotoxic T cells
adoptive transfer
transgenic T cell receptor
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2018.02665/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2018.02665/full

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