Loss of N-Glycanase 1 Alters Transcriptional and Translational Regulation in K562 Cell Lines

Loss of N-Glycanase 1 Alters Transcriptional and Translational Regulation in K562 Cell Lines

N-Glycanase 1 (NGLY1) deficiency is an ultra-rare, complex and devastating neuromuscular disease. Patients display multi-organ symptoms including developmental delays, movement disorders, seizures, constipation and lack of tear production. NGLY1 is a deglycosylating protein involved in the degradati...

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Bibliographic Details
Main Authors: William F. Mueller, Petra Jakob, Han Sun, Sandra Clauder-Münster, Sonja Ghidelli-Disse, Diana Ordonez, Markus Boesche, Marcus Bantscheff, Paul Collier, Bettina Haase, Vladimir Benes, Malte Paulsen, Peter Sehr, Joe Lewis, Gerard Drewes, Lars M. Steinmetz
Format: Article
Language:English
Published: Oxford University Press 2020-05-01
Series:G3: Genes, Genomes, Genetics
Subjects:
autophagy
deglycosylation
nfe2l1
ngly1deficiency
nrf1
Online Access:http://g3journal.org/lookup/doi/10.1534/g3.119.401031

Internet

http://g3journal.org/lookup/doi/10.1534/g3.119.401031

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