xCT Inhibition Increases Sensitivity to Vorinostat in a ROS-Dependent Manner

xCT Inhibition Increases Sensitivity to Vorinostat in a ROS-Dependent Manner

As histone deacetylase inhibitors (HDACIs) have limited efficacy against solid tumors, we investigated whether and how oxidative stress is involved in sensitivity to HDACIs to develop a novel therapeutic option of HDACIs treatment. We first tested whether a reduction of the antioxidant glutathione (...

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Bibliographic Details
Main Authors: Keiko Miyamoto, Motoki Watanabe, Shogen Boku, Mamiko Sukeno, Mie Morita, Haruhito Kondo, Koichi Sakaguchi, Tetsuya Taguchi, Toshiyuki Sakai
Format: Article
Language:English
Published: MDPI AG 2020-03-01
Series:Cancers
Subjects:
vorinostat
HDAC inhibitor
glutathione
ROS
xCT
salazosulfapyridine
Online Access:https://www.mdpi.com/2072-6694/12/4/827

Internet

https://www.mdpi.com/2072-6694/12/4/827

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