A progesterone biosensor derived from microbial screening

A progesterone biosensor derived from microbial screening

Bacteria represent an unexploited reservoir of biosensing proteins. Here the authors use genomic screens and functional assays to isolate a progesterone sensing allosteric transcription factor and use a FRET-based method to develop an optical progesterone sensor.

Bibliographic Details
Main Authors: Chloé Grazon, R C. Baer, Uroš Kuzmanović, Thuy Nguyen, Mingfu Chen, Marjon Zamani, Margaret Chern, Patricia Aquino, Xiaoman Zhang, Sébastien Lecommandoux, Andy Fan, Mario Cabodi, Catherine Klapperich, Mark W. Grinstaff, Allison M. Dennis, James E. Galagan
Format: Article
Language:English
Published: Nature Publishing Group 2020-03-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-020-14942-5

Internet

https://doi.org/10.1038/s41467-020-14942-5

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