Small Molecule-Based Prodrug Targeting Prostate Specific Membrane Antigen for the Treatment of Prostate Cancer

Small Molecule-Based Prodrug Targeting Prostate Specific Membrane Antigen for the Treatment of Prostate Cancer

Metastatic castration-resistant prostate cancer poses a serious clinical problem with poor outcomes and remains a deadly disease. New targeted treatment options are urgently needed. PSMA is highly expressed in prostate cancer and has been an attractive biomarker for the treatment of prostate cancer....

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Bibliographic Details
Main Authors: Xinning Wang, Aditi Shirke, Ethan Walker, Rongcan Sun, Gopolakrishnan Ramamurthy, Jing Wang, Lingpeng Shan, Joey Mangadlao, Zhipeng Dong, Jing Li, Ziying Wang, Mark Schluchter, Dong Luo, Yu Wang, Shaun Stauffer, Susann Brady-Kalnay, Christopher Hoimes, Zhenghong Lee, James P. Basilion
Format: Article
Language:English
Published: MDPI AG 2021-01-01
Series:Cancers
Subjects:
prostate cancer
prostate specific membrane antigen (PSMA)
prodrug
monomethyl auristatin E (MMAE)
Online Access:https://www.mdpi.com/2072-6694/13/3/417

Internet

https://www.mdpi.com/2072-6694/13/3/417

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