Promyelocytic Leukemia Restricts Enterovirus 71 Replication by Inhibiting Autophagy

Promyelocytic Leukemia Restricts Enterovirus 71 Replication by Inhibiting Autophagy

The promyelocytic leukemia (PML) protein, also known as TRIM19, functions as a major organizer of PML nuclear bodies (NBs) in most mammalian cells and plays important roles in antiviral activities against both DNA and RNA viruses. In this study, we found that the downregulation of PML rendered HeLa...

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Bibliographic Details
Main Authors: Deyan Chen, Chunhong Feng, Xiaoyan Tian, Nan Zheng, Zhiwei Wu
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-06-01
Series:Frontiers in Immunology
Subjects:
promyelocytic leukemia
promyelocytic leukemia protein-nuclear bodies
enterovirus 71
autophagy
3Cpro
interferon-β
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2018.01268/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2018.01268/full

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