Axonal degeneration in an Alzheimer mouse model is PS1 gene dose dependent and linked to intraneuronal Aß accumulation

Axonal degeneration in an Alzheimer mouse model is PS1 gene dose dependent and linked to intraneuronal Aß accumulation

Abnormalities and impairments in axonal transport are suggested to strongly contribute to the pathological alterations underlying AD. The exact mechanisms leading to axonopathy are currently unclear, but it was recently suggested that APP expression itself triggers axonal degeneration. We used APP t...

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Bibliographic Details
Main Authors: Ditte Zerlang Christensen, Melanie eHüttenrauch, Miso eMitkovski, Laurent ePradier, Oliver eWirths
Format: Article
Language:English
Published: Frontiers Media S.A. 2014-06-01
Series:Frontiers in Aging Neuroscience
Subjects:
Alzheimer Disease
Amyloid
Axonal Transport
Transgenic mice
intraneuronal amyloid-beta
Presenilin
Online Access:http://journal.frontiersin.org/Journal/10.3389/fnagi.2014.00139/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fnagi.2014.00139/full

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