Targeted Mutation (R100W) of the Gene Encoding NGF Leads to Deficits in the Peripheral Sensory Nervous System

Nerve growth factor (NGF) exerts multifaceted functions through different stages of life. A missense mutation (R100W) in the beta-NGF gene was found in hereditary sensory autonomic neuropathy V (HSAN V) patients with severe loss of pain perception but without overt cognitive impairment. To better un...

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Bibliographic Details
Main Authors: Wanlin Yang, Kijung Sung, Fengli Zhou, Wei Xu, Robert A. Rissman, Jianqing Ding, Chengbiao Wu
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-11-01
Series:Frontiers in Aging Neuroscience
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Online Access:https://www.frontiersin.org/article/10.3389/fnagi.2018.00373/full