The development of a GPR44 targeting radioligand [11C]AZ12204657 for in vivo assessment of beta cell mass

The development of a GPR44 targeting radioligand [11C]AZ12204657 for in vivo assessment of beta cell mass

Abstract Background The G-protein-coupled receptor 44 (GPR44) is a beta cell-restricted target that may serve as a marker for beta cell mass (BCM) given the development of a suitable PET ligand. Methods The binding characteristics of the selected candidate, AZ12204657, at human GPR44 were determined...

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Bibliographic Details
Main Authors: Mahabuba Jahan, Peter Johnström, Ram K. Selvaraju, Marie Svedberg, Maria Sörhede Winzell, Jenny Bernström, Lee Kingston, Magnus Schou, Zhisheng Jia, Stanko Skrtic, Lars Johansson, Olle Korsgren, Lars Farde, Christer Halldin, Olof Eriksson
Format: Article
Language:English
Published: SpringerOpen 2018-12-01
Series:EJNMMI Research
Subjects:
G-protein-coupled receptor 44 (GPR44)
Beta cell imaging
Islet imaging
Beta cell mass
Diabetes
Online Access:http://link.springer.com/article/10.1186/s13550-018-0465-6

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http://link.springer.com/article/10.1186/s13550-018-0465-6

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