MitoRS, a method for high throughput, sensitive, and accurate detection of mitochondrial DNA heteroplasmy

MitoRS, a method for high throughput, sensitive, and accurate detection of mitochondrial DNA heteroplasmy

Abstract Background Mitochondrial dysfunction is linked to numerous pathological states, in particular related to metabolism, brain health and ageing. Nuclear encoded gene polymorphisms implicated in mitochondrial functions can be analyzed in the context of classical genome wide association studies....

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Bibliographic Details
Main Authors: Julien Marquis, Gregory Lefebvre, Yiannis A. I. Kourmpetis, Mohamed Kassam, Frédéric Ronga, Umberto De Marchi, Andreas Wiederkehr, Patrick Descombes
Format: Article
Language:English
Published: BMC 2017-04-01
Series:BMC Genomics
Subjects:
Next generation sequencing
Mitochondria
Mitochondrial DNA
Heteroplasmy
Rolling circle amplification
Somatic mutation
Online Access:http://link.springer.com/article/10.1186/s12864-017-3695-5

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http://link.springer.com/article/10.1186/s12864-017-3695-5

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