Depletion of Histone Demethylase Jarid1A Resulting in Histone Hyperacetylation and Radiation Sensitivity Does Not Affect DNA Double-Strand Break Repair.

Depletion of Histone Demethylase Jarid1A Resulting in Histone Hyperacetylation and Radiation Sensitivity Does Not Affect DNA Double-Strand Break Repair.

Histone demethylases have recently gained interest as potential targets in cancer treatment and several histone demethylases have been implicated in the DNA damage response. We investigated the effects of siRNA-mediated depletion of histone demethylase Jarid1A (KDM5A, RBP2), which demethylates trans...

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Bibliographic Details
Main Authors: Corina Penterling, Guido A Drexler, Claudia Böhland, Ramona Stamp, Christina Wilke, Herbert Braselmann, Randolph B Caldwell, Judith Reindl, Stefanie Girst, Christoph Greubel, Christian Siebenwirth, Wael Y Mansour, Kerstin Borgmann, Günther Dollinger, Kristian Unger, Anna A Friedl
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2016-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4890786?pdf=render

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http://europepmc.org/articles/PMC4890786?pdf=render

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