Increased expression of the androgen receptor with p300 and interleukin-6 coactivators compensate for oligonucleotide suppression of bcl-2: no increased CREB binding protein or interleukin-4 expression

Background: Antisense oligonucleotides (oligos) have been employed against in vivo and in vitro prostate cancer models targeting growth regulatory proteins. While most oligos have targeted growth factors or their receptors, others have been directed against inhibitors of apoptosis and mediators of a...

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Bibliographic Details
Main Authors: Marvin Rubenstein, Courtney M.P. Hollowell, Patrick Guinan
Format: Article
Language:English
Published: SAGE Publishing 2013-04-01
Series:Therapeutic Advances in Urology
Online Access:https://doi.org/10.1177/1756287212466281