Could We Address the Interplay Between CD133, Wnt/β-Catenin, and TERT Signaling Pathways as a Potential Target for Glioblastoma Therapy?

Could We Address the Interplay Between CD133, Wnt/β-Catenin, and TERT Signaling Pathways as a Potential Target for Glioblastoma Therapy?

Glioblastoma multiforme (GBM) is one of the most lethal forms of primary brain tumors. Glioblastoma stem cells (GSCs) play an undeniable role in tumor development by activating multiple signaling pathways such as Wnt/β-catenin and PI3K/AKT/mTOR that facilitate brain tumor formation. CD133, a transme...

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Bibliographic Details
Main Authors: Amir Barzegar Behrooz, Amir Syahir
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-04-01
Series:Frontiers in Oncology
Subjects:
glioblastoma stem cells
CD133
Wnt/β-catenin
PI3K/AKT/mTOR
telomerase
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2021.642719/full

Internet

https://www.frontiersin.org/articles/10.3389/fonc.2021.642719/full

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