The Interaction of the Tumor Suppressor FAM46C with p62 and FNDC3 Proteins Integrates Protein and Secretory Homeostasis

The Interaction of the Tumor Suppressor FAM46C with p62 and FNDC3 Proteins Integrates Protein and Secretory Homeostasis

Summary: FAM46C is a non-canonical poly(A) polymerase uniquely mutated in up to 20% of multiple myeloma (MM) patients, implying a tissue-specific tumor suppressor function. Here, we report that FAM46C selectively stabilizes mRNAs encoding endoplasmic reticulum (ER)-targeted proteins, thereby concert...

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Bibliographic Details
Main Authors: Chiara Fucci, Massimo Resnati, Elena Riva, Tommaso Perini, Elena Ruggieri, Ugo Orfanelli, Francesca Paradiso, Floriana Cremasco, Andrea Raimondi, Elena Pasqualetto, Mario Nuvolone, Luca Rampoldi, Simone Cenci, Enrico Milan
Format: Article
Language:English
Published: Elsevier 2020-09-01
Series:Cell Reports
Subjects:
antibody
autophagy
bortezomib
endoplasmic reticulum
FAM46C
FNDC3B
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124720311517

Internet

http://www.sciencedirect.com/science/article/pii/S2211124720311517

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