A role for telomere length and chromosomal damage in idiopathic pulmonary fibrosis

A role for telomere length and chromosomal damage in idiopathic pulmonary fibrosis

Abstract Background Idiopathic pulmonary fibrosis is a fatal lung disease characterized by a progressive formation of fibroblastic foci in the interstitium. This disease is strongly associated with telomere dysfunction but the extent of telomere shortening and consequent chromosomal damage within IP...

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Bibliographic Details
Main Authors: John E. McDonough, Dries S. Martens, Naoya Tanabe, Farida Ahangari, Stijn E. Verleden, Karen Maes, Geert M. Verleden, Naftali Kaminski, James C. Hogg, Tim S. Nawrot, Wim A. Wuyts, Bart M. Vanaudenaerde
Format: Article
Language:English
Published: BMC 2018-07-01
Series:Respiratory Research
Subjects:
IPF
Telomere length
Gamma-H2AX
Fibrosis
Collagen 1
Elastin
Online Access:http://link.springer.com/article/10.1186/s12931-018-0838-4

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http://link.springer.com/article/10.1186/s12931-018-0838-4

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