MEF2C repressor variant deregulation leads to cell cycle re-entry and development of heart failure

MEF2C repressor variant deregulation leads to cell cycle re-entry and development of heart failure

Background: A pathophysiological link exists between dysregulation of MEF2C transcription factors and heart failure (HF), but the underlying mechanisms remain elusive. Alternative splicing of MEF2C exons α, β and γ provides transcript diversity with gene activation or repression functionalities. Met...

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Bibliographic Details
Main Authors: Ana Helena M. Pereira, Alisson C. Cardoso, Silvio R. Consonni, Renata R. Oliveira, Angela Saito, Maria Luisa B. Vaggione, Jose R. Matos-Souza, Marcelo F. Carazzolle, Anderson Gonçalves, Juliano L. Fernandes, Gustavo C.A. Ribeiro, Mauricio M. Lopes, Jeffery D. Molkentin, Kleber G. Franchini
Format: Article
Language:English
Published: Elsevier 2020-01-01
Series:EBioMedicine
Online Access:http://www.sciencedirect.com/science/article/pii/S2352396419307819

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http://www.sciencedirect.com/science/article/pii/S2352396419307819

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