Acyclovir Has Low but Detectable Influence on HLA-B*57:01 Specificity without Inducing Hypersensitivity.

Acyclovir Has Low but Detectable Influence on HLA-B*57:01 Specificity without Inducing Hypersensitivity.

Immune mediated adverse drug reactions (IM-ADRs) remain a significant source of patient morbidity that have more recently been shown to be associated with specific class I and/or II human leukocyte antigen (HLA) alleles. Abacavir-induced hypersensitivity syndrome is a CD8+ T cell dependent IM-ADR th...

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Bibliographic Details
Main Authors: Imir G Metushi, Amanda Wriston, Priyanka Banerjee, Bjoern Oliver Gohlke, A Michelle English, Andrew Lucas, Carrie Moore, John Sidney, Soren Buus, David A Ostrov, Simon Mallal, Elizabeth Phillips, Jeffrey Shabanowitz, Donald F Hunt, Robert Preissner, Bjoern Peters
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4449000?pdf=render

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http://europepmc.org/articles/PMC4449000?pdf=render

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