Regulation of the opposing (p)ppGpp synthetase and hydrolase activities in a bifunctional RelA/SpoT homologue from Staphylococcus aureus.

Regulation of the opposing (p)ppGpp synthetase and hydrolase activities in a bifunctional RelA/SpoT homologue from Staphylococcus aureus.

The stringent response is characterized by (p)ppGpp synthesis resulting in repression of translation and reprogramming of the transcriptome. In Staphylococcus aureus, (p)ppGpp is synthesized by the long RSH (RelA/SpoT homolog) enzyme, RelSau or by one of the two short synthetases (RelP, RelQ). RSH e...

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Bibliographic Details
Main Authors: Fabio Lino Gratani, Petra Horvatek, Tobias Geiger, Marina Borisova, Christoph Mayer, Iwan Grin, Samuel Wagner, Wieland Steinchen, Gert Bange, Ana Velic, Boris Maček, Christiane Wolz
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2018-07-01
Series:PLoS Genetics
Online Access:http://europepmc.org/articles/PMC6053245?pdf=render

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http://europepmc.org/articles/PMC6053245?pdf=render

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