proBDNF Negatively Regulates Neuronal Remodeling, Synaptic Transmission, and Synaptic Plasticity in Hippocampus

proBDNF Negatively Regulates Neuronal Remodeling, Synaptic Transmission, and Synaptic Plasticity in Hippocampus

Experience-dependent plasticity shapes postnatal development of neural circuits, but the mechanisms that refine dendritic arbors, remodel spines, and impair synaptic activity are poorly understood. Mature brain-derived neurotrophic factor (BDNF) modulates neuronal morphology and synaptic plasticity,...

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Bibliographic Details
Main Authors: Jianmin Yang, Lauren C. Harte-Hargrove, Chia-Jen Siao, Tina Marinic, Roshelle Clarke, Qian Ma, Deqiang Jing, John J. LaFrancois, Kevin G. Bath, Willie Mark, Douglas Ballon, Francis S. Lee, Helen E. Scharfman, Barbara L. Hempstead
Format: Article
Language:English
Published: Elsevier 2014-05-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S221112471400237X

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http://www.sciencedirect.com/science/article/pii/S221112471400237X

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