CD73 Ectonucleotidase Restrains CD8+ T Cell Metabolic Fitness and Anti-tumoral Activity

CD73 Ectonucleotidase Restrains CD8+ T Cell Metabolic Fitness and Anti-tumoral Activity

CD39 and CD73 are ectoenzymes that dephosphorylate ATP into its metabolites; ADP, AMP, and adenosine, and thus are considered instrumental in the development of immunosuppressive microenvironments. We have previously shown that within the CD8+ T cell population, naïve and memory cells express the CD...

Full description

Bibliographic Details
Main Authors: Pedro Briceño, Elizabeth Rivas-Yañez, Mariana V. Rosemblatt, Brian Parra-Tello, Paula Farías, Leonardo Vargas, Valeska Simon, César Cárdenas, Alvaro Lladser, Flavio Salazar-Onfray, Alvaro A. Elorza, Mario Rosemblatt, María Rosa Bono, Daniela Sauma
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-02-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
CD73/NT5E
CD8 T cell
metabolism
cytotoxic
antitumor activity
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2021.638037/full

Internet

https://www.frontiersin.org/articles/10.3389/fcell.2021.638037/full

Similar Items